DNA repair aging refers to the age-associated decline in the efficiency and coordination of DNA repair pathways. These pathways include base excision repair, nucleotide excision repair, mismatch repair, and double-strand break repair. With aging, reduced repair capacity leads to increased mutation burden and compromised genomic integrity. Defects in DNA repair accelerate aging and are linked to premature aging syndromes. Declining DNA repair contributes to cellular senescence, stem cell exhaustion, and tissue dysfunction. Maintaining robust DNA repair mechanisms is essential for preserving cellular health and preventing age-related diseases. Enhancing DNA repair function represents a promising strategy to mitigate aging-related genomic decline.
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