DNA methylation aging refers to age-related changes in methylation patterns at specific cytosine residues throughout the genome. These changes accumulate predictably over time and form the molecular basis of epigenetic clocks. DNA methylation influences gene expression, cellular identity, and genomic stability. With aging, methylation patterns show increased variability, loss of regulatory precision, and altered control of developmental and metabolic pathways. DNA methylation aging is sensitive to environmental exposures, lifestyle factors, and disease states, making it a powerful indicator of biological aging. Because methylation changes are potentially reversible, they are being explored as targets for aging interventions and health optimization strategies.
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Kenneth R Pelletier, University of California School of Medicine, United States
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