Clearance of senescent cells refers to biological processes that remove senescent cells from tissues. In young organisms, immune surveillance efficiently eliminates senescent cells to maintain tissue health. With aging, clearance mechanisms weaken, allowing senescent cells to accumulate. Impaired clearance contributes to increased inflammation, tissue dysfunction, and disease risk. Effective clearance restores tissue function and improves regenerative capacity. Understanding clearance of senescent cells highlights importance of immune-mediated maintenance mechanisms in controlling aging progression and preserving tissue integrity.
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