Circadian rhythm aging describes progressive disruption of internal biological clocks that regulate daily physiological cycles. These rhythms control sleep–wake patterns, hormone secretion, metabolism, immune activity, and body temperature. With aging, circadian amplitude weakens and timing becomes fragmented. Cellular clocks lose synchronization, reducing coordination between tissues. Circadian rhythm aging contributes to sleep disturbances, metabolic dysfunction, hormonal imbalance, and increased disease risk. Environmental cues such as light exposure become less effective in entraining rhythms. Disrupted circadian regulation also impairs stress responses and immune function. Understanding circadian rhythm aging emphasizes the importance of temporal regulation in maintaining physiological resilience and healthspan during aging.
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