Cellular aging describes the functional and structural changes that occur in cells as they age. A central feature is cellular senescence, a state of permanent growth arrest accompanied by altered gene expression and inflammatory signaling. Other aspects include telomere attrition, mitochondrial dysfunction, DNA damage accumulation, and impaired autophagy. Aging cells exhibit reduced stress resistance and diminished ability to maintain homeostasis. Senescent cells can negatively impact surrounding tissues through the senescence-associated secretory phenotype (SASP), contributing to inflammation and tissue degeneration. Understanding cellular aging is critical for developing therapies such as senolytics and regenerative strategies aimed at restoring tissue function and delaying age-related decline.
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom