Cell cycle arrest aging refers to increased prevalence of permanent or prolonged cell cycle arrest in aging tissues. Cells enter arrest in response to DNA damage, telomere shortening, or stress to prevent propagation of damaged genomes. While protective against cancer, widespread cell cycle arrest reduces regenerative capacity and contributes to tissue degeneration. Arrested cells often acquire senescent phenotypes that promote inflammation and tissue dysfunction. Cell cycle arrest aging reflects a trade-off between genome stability and tissue renewal. Understanding this process helps explain declining regenerative potential and increased frailty during aging.
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