Calorie sensing pathways aging describes age-related dysregulation of molecular systems that detect and respond to caloric availability. These pathways regulate growth, metabolism, and cellular maintenance by adjusting anabolic and catabolic processes. With aging, calorie sensing becomes biased toward growth signaling at the expense of repair and recycling. This imbalance promotes accumulation of damaged cellular components. Calorie sensing pathways aging contributes to reduced stress resistance and metabolic inefficiency. Declining responsiveness limits adaptive benefits of nutrient scarcity. Understanding how calorie sensing pathways age provides insight into mechanisms linking nutrition to longevity and metabolic health.
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