Blood brain barrier aging refers to progressive deterioration of the barrier that separates circulating blood from neural tissue. This barrier regulates transport of nutrients, metabolites, and immune cells while preventing entry of harmful substances. With aging, barrier integrity weakens due to endothelial dysfunction, inflammation, and altered tight junction structure. Increased permeability allows inflammatory mediators and toxins to enter the brain, promoting neuroinflammation and neuronal stress. Blood brain barrier aging disrupts metabolic exchange and impairs neural protection. This decline contributes to cognitive impairment and increased risk of neurodegenerative disorders. Understanding blood brain barrier aging highlights vascular health as a critical determinant of brain aging.
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