World Aging & Longevity Conference
October 08-10, 2026
B Cell Aging
B cell aging refers to age-associated changes in development, diversity, and function of B lymphocytes responsible for antibody production. With aging, bone marrow output of naïve B cells declines, reducing repertoire diversity. Aging B cells show impaired class switching, reduced antibody affinity, and altered signaling responses. These changes weaken humoral immunity and reduce effectiveness of responses to new pathogens. B cell aging also promotes accumulation of dysfunctional memory B cells that contribute to chronic inflammation and autoimmunity. Altered cytokine environments and metabolic stress further impair B cell function. B cell aging plays a major role in reduced vaccine efficacy and increased infection risk in older adults. Understanding B cell aging provides insight into immune system remodeling and highlights the need for age-adapted immunization strategies.
Kenneth R Pelletier
University of California School of Medicine, United States
Thomas J Webster
Brown University, United States
Jason Beckwith
BioTalent, United Kingdom
Sergey Suchkov
N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Jose Cordeiro Mateo
International Longevity Summit, Spain
Ashot Khachatryan
National Academy of Sciences of the Republic of Armenia, Armenia
Utpol Das
University of Texas Medical Branch at Galveston, United StatesSubmit your abstract Today
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom