Andropause refers to gradual age-associated decline in androgen levels, particularly testosterone, in males. Unlike menopause, andropause is progressive and variable across individuals. Declining testosterone affects muscle mass, bone density, fat distribution, energy metabolism, mood, and cognitive function. Andropause is also associated with reduced anabolic signaling and altered cardiovascular and metabolic regulation. Chronic inflammation and metabolic stress can exacerbate hormonal decline. Andropause reflects interaction between endocrine aging and systemic biological aging processes. Understanding andropause provides insight into male-specific aging trajectories and highlights the role of hormonal regulation in maintaining functional health and resilience across the lifespan.
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