AMPK aging describes age-related alterations in the activity of AMP-activated protein kinase, a master regulator of cellular energy balance. AMPK is activated during low-energy conditions and promotes energy-producing processes while suppressing energy-consuming pathways. With aging, reduced AMPK responsiveness contributes to metabolic imbalance, mitochondrial dysfunction, and increased oxidative stress. AMPK activation enhances autophagy, improves mitochondrial quality, and supports cellular stress resistance. Declining AMPK signaling is linked to impaired metabolic adaptation and reduced healthspan. AMPK aging highlights the importance of energy sensing in maintaining cellular homeostasis and resilience during aging. Enhancing AMPK activity remains a promising strategy to counteract metabolic decline and promote healthy aging.
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom