Amino acid sensing aging refers to altered cellular detection and response to amino acid availability with age. Amino acid sensing regulates protein synthesis, autophagy, and metabolic signaling. Aging disrupts this balance, favoring excessive protein synthesis while suppressing recycling processes. Impaired amino acid sensing aging contributes to proteostasis loss, metabolic strain, and reduced cellular adaptability. Elevated circulating amino acids also promote inflammatory signaling. Understanding amino acid sensing aging highlights how nutrient quality influences aging biology and cellular maintenance capacity.
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