Aging mechanisms are the underlying biological processes that drive aging at multiple levels of organization. Widely recognized mechanisms include genomic instability, telomere shortening, epigenetic alterations, mitochondrial dysfunction, cellular senescence, and dysregulated nutrient sensing. These mechanisms interact in complex networks, amplifying age-related damage and functional decline. Aging mechanisms are highly conserved across species, suggesting shared evolutionary origins. Studying these mechanisms has enabled the identification of potential intervention targets, such as mTOR inhibition, caloric restriction mimetics, and senolytic therapies. Understanding aging mechanisms is fundamental to shifting medicine from disease treatment to aging intervention and prevention.
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom