Aging hallmark pathways are the molecular signaling networks that regulate and connect the hallmarks of aging. These pathways control cellular stress responses, metabolism, growth, repair, and survival. Dysregulation of hallmark pathways accelerates aging and increases susceptibility to disease. Many hallmark pathways are evolutionarily conserved and responsive to environmental and lifestyle factors. Their interconnected nature allows interventions targeting one pathway to influence multiple aging processes. Studying aging hallmark pathways enables mechanistic insight into aging regulation and provides a roadmap for designing interventions that promote resilience, longevity, and functional health across the lifespan.
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Kenneth R Pelletier, University of California School of Medicine, United States
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Thomas J Webster, Brown University, United States
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