Aging and metabolism are closely interconnected, as metabolic regulation changes progressively over the lifespan. Aging alters glucose utilization, lipid handling, and energy production efficiency. Reduced metabolic flexibility limits the ability to adapt to nutritional or physiological stress. Mitochondrial function declines with age, contributing to reduced energy availability and increased oxidative stress. Hormonal changes further disrupt metabolic coordination across tissues. Aging and metabolism influence inflammation, immune function, and tissue repair capacity. Metabolic dysfunction accelerates biological aging and increases risk of chronic disease. Understanding the relationship between aging and metabolism provides a foundation for interventions aimed at preserving energy balance and systemic resilience during aging.
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