Aging and insulin resistance are interconnected through changes in metabolic signaling and tissue responsiveness. With aging, muscle, liver, and adipose tissue become less responsive to insulin, impairing glucose uptake and regulation. Mitochondrial dysfunction, inflammation, and lipid accumulation contribute to insulin resistance development. Reduced physical activity and hormonal shifts further exacerbate these changes. Aging and insulin resistance promote metabolic instability and increase risk of diabetes and cardiovascular disease. Insulin resistance also influences brain function and accelerates biological aging. Understanding this relationship is essential for maintaining metabolic resilience and preventing age-related disease progression.
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