Age related muscle loss describes gradual decline in muscle mass and force generation that accompanies aging. This process results from reduced muscle protein synthesis, increased catabolism, impaired satellite cell activation, and altered neuromuscular control. Age related muscle loss diminishes physical capacity, slows gait speed, and increases fall risk. It also affects whole-body metabolism, contributing to insulin resistance and reduced energy expenditure. Muscle loss progresses at varying rates depending on genetics, activity level, and health status. Addressing age related muscle loss is critical for preserving mobility, functional independence, and overall healthspan during aging.
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