Age related immune dysfunction encompasses broad decline in immune defense, regulation, and adaptability with age. Both innate and adaptive immunity are affected through reduced cell diversity, impaired signaling, and chronic inflammation. Immune dysfunction aging leads to increased infection risk, reduced vaccine efficacy, and higher incidence of autoimmunity and cancer. Declining immune surveillance compromises tissue maintenance and repair. Age related immune dysfunction reflects cumulative cellular damage and systemic dysregulation. Understanding immune dysfunction aging is critical for improving healthspan and disease resistance in older adults.
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