Accumulated cellular damage aging describes progressive buildup of structural and functional damage within cells over the lifespan. This damage includes mitochondrial defects, protein aggregation, genomic instability, and impaired organelle turnover. As damage accumulates, cells lose efficiency and adaptability. Accumulated cellular damage aging reduces tissue repair capacity and promotes inflammation and degeneration. This process affects all tissues and is a core feature of biological aging. Cellular damage accumulation reflects imbalance between damage generation and repair efficiency. Understanding this process provides a unifying framework for aging biology and supports strategies that enhance cellular maintenance and resilience.
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom