The tumor core-periphery architecture: A mathematical model for biodistribution of nanocarriers

Title : The tumor core-periphery architecture: A mathematical model for biodistribution of nanocarriers

Abstract:

Tumor growth is a highly complex biological event that involves not only malignant cells’ proliferation but also a huge proliferation movement of supportive tissues that allow tumor growth. Included in these supportive elements, blood vessels may grow in differential patterns, depending upon the sub-tumoral localization. This heterogeneous vascular organization produces regions with differential vessel density, which may impact significantly nanocarriers distribution within different tumor areas. This talk will focus on the description of a comprehensive mathematical model, describing the differential nanoemulsion biodistribution and sub-tumoral localization in two different breast cancer models (4T1 and Ehrlich). To account for the assessed biodistribution data, the tumor region is modeled using an interconnected compartment-like (core-periphery) morphology. It will be emphasized that the time dependence of the nanocarrier content in each compartment is successfully accomplished while the parameters extracted from the proposed approach can be extremely useful for planning therapeutic protocols.

Biography:

Professor Paulo César De Morais (H63), PhD, was full Professor of Physics at the University of Brasilia (UnB) – Brazil up to 2013. Appointed as UnB’s (Brazil) Emeritus Professor (2014); Visiting Professor at the Huazhong University of Science and Technology (HUST) – China (2012-2015); Distinguished Professor at the Anhui University (AHU) – China (2016-2019); Full Professor at the Catholic University of Brasília (UCB) – Brazil (2018); CNPq-1A Research Fellow since 2010; 2007 Master Research Prize from UnB. He held two-years (1987-1988) post-doc position with Bell Communications Research, New Jersey – USA and received his Doctoral degree in Solid State Physics (1986) from the Federal University of Minas Gerais (UFMG) – Brazil. With more than 14,500 citations, He has published more than 500 papers (Web of Science), presented around 300 international invited talks (35 countries), and filed 16 patents.